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In contrast, ZIP1 is downregulated in malignant cells, resulting in the inability to accumulate zinc
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13 :e1002202 94
Zolfagharai EJ, Ayoadeu O, Antonoff MB
fumigatus has at least seven chitin synthase encoding genes, but just four of them have been assayed for virulence: chsC, chsD, chsE, and chsG.14,177179 Only chsG seems to have an influence on virulence, with a chsG mutant strain having been shown to produce lower mortality rates than the reference strain in a mice infection model.177 However, these results could also be explained by redundancy of this type of enzymes
