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GSSG can be converted back to GSH with the aid of the enzyme glutathione reductase 5

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However, large single doses of vitamin C can cause gastrointestinal upset, so people with sensitive stomachs could experience cramping, gas, or diarrhea

April 2001;41(1):7999

Minimizing unnecessary polypharmacy, such as NSAIDs and loop diuretics, is essential to prevent adverse drug reactions, particularly in elderly patients who require close monitoring