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Future strategies should incorporate personalized microbiome profiling, enabling tailored interventions that target individual microbial deficiencies, optimize immune modulation, and maximize therapeutic efficacy (Porcari et al., 2023)

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Recently, we developed a NASH C57BL/6 J mouse model using a P-HFD supplemented with intraperitoneal injections of LPS to simulate gut dysbiosis and endotoxemia