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There are two models of alignment of the homologous genes, the inverted and tandem duplication models [12,36]

Gene expression analysis revealed an upregulation of inflammatory mediators such as IL8, CXCL13, and arginase-1 (ARG1), as well as genes associated with oxidative stress response including superoxide dismutase 2 (SOD2) and angiopoietin-like 4 (ANGPTL4) (69)

The staining of SIRT1 was measured using FL6 detector (633 nm excitation, 660/20 nm emission)

DOI: 10.1177/0004563215594818