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Physicians commonly assume that taking oral supplements will be associated with a feeling of greater well-being, although this has never been proven [40]

However, the deficiency continues, and cellular dysfunction begins

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There is also some limited evidence suggesting that individuals who carry certain polymorphisms in genes involved in vitamin C transport and detoxification mechanisms may have lower plasma vitamin C concentrations even with high vitamin C intakes (see also Vascular complications of diabetes mellitus) (reviewed in 27)