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In the cryopreservation of solid organs, the grafts were initially perfused with standard organ preservation solutions (e.g., UW solution) and subsequently stored at low temperatures (approximately 4) for preservation

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Key factors hindering the healing of diabetic wounds include persistent high level of reactive oxygen species (ROS), excessive inflammatory cells and cytokines in the wound microenvironment, insufficient new blood vessel formation, and weakened cell proliferation 21,22