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Several mutations that impair the somatotropic axis have been associated with increased lifespan in mice

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doi: 10.1515/cclm.1995.33.4.179

PTMs involved in regulation of TF stability TF levels are determined by a balance between biosynthesis and degradation, both regulated by cellular signals and specific PTMs that direct TFs to degradation pathways

However, as explained above, the other factors will allow distinguishing them
