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This amino acid can also be converted into fumaric acid and acetoacetate, thereby participating in the tricarboxylic acid cycle and providing energy for various biochemical reactions, such as oxidative stress regulation [56]

2.2.2 Effects of mtROS on immune cell activation in the TME To avoid the deleterious effects of high ROS levels on immune cells, there exists a set of strict regulatory mechanisms in the organism to maintain a delicate balance between immune cell activity and ROS levels (46)

FDA does not intend to apply the more permissive policy used for Category 1 while evaluation continues)

J.PosaL.Ochoa-SanchezR.EnnsJ.Lopez-CanulM.et al (2019)