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A 2025 systematic review by Vasireddi and colleagues in HSS Journal screened 544 published papers and identified 36 meeting inclusion criteria 35 preclinical studies and only one human study: an uncontrolled, unblinded, retrospective case series of 12 patients receiving intra-articular BPC-157 for chronic knee pain, in which 7 of 12 (58%) reported self-described relief lasting more than 6 months, with no dose, effect size, or systematically collected adverse events published

Transparency about the regulatory status of the treatment : A responsible doctor will clearly explain whether a proposed treatment is HSA-approved for its intended use, or whether it constitutes off-label use, and will document informed consent accordingly

doi:10.1007/BF02284971 35

The printing ink was prepared by mixing 0.03% alcohol-soluble aniline black with 99.97% PDMS (SE 1700, Dow Corning, USA)

Seifi M, Brown JF, Mills J, et al