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It is one of the most common health problems and accounts for more outpatient antibiotic prescriptions than any other diagnosis.1 Both host and environmental factors play a role in the development of rhinosinusitis

Nevertheless, they can offer meaningful symptom relief in carefully selected patients through distinct neuromodulatory pathways

Other upstream factors, such as decreased input to GABAergic neurons (Akbarian and Huang, 2006), and a reduction in Zif268, a transcription factor that regulates GAD67 expression, in postmortem brains of individuals with schizophrenia have also been reported (Kimoto et al., 2014)

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You may also have numb or tingly hands and feet, which are signs of nerve problems