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At nanomolar concentrations, GHK-Cu may act primarily as a signaling molecule, while higher concentrations in some models have shown different activity profiles

The phosphorylated analogue of DSIP enhances slow wave sleep and paradoxical sleep in unrestrained rats

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This finding could be explained by the previous in vitro data (Rathz et al., 2002) given that 1 -AR overactivation increases the workload on a failing heart (Masarone et al., 2021)