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Hence, age and its relation to liver regenerative capabilities and the extent of inflammation may have a significant impact on patients outcomes that should further be assessed

[DOI] [PMC free article] [PubMed] [Google Scholar] 114.Smagris E., Gilyard S., BasuRay S., Cohen J.C., Hobbs H.H

It was suggested that the instigator of the molecular and proteomic modifications includes an increase in the production of ROS, elevated stress proteins levels and higher levels of redox and inflammatory proteins

ROS-induced caspase-3 and calpains also degrade cytoskeletal proteins, promoting UPS substrate supply