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Curcumin was found to reduce the expression of DNA methyltransferase 1 and DNA methyltransferase 3a in a dose-dependent manner, which correlated with a significant decrease in methylation at the promoter region of the caudal type homeobox 2 gene

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Despite evidence of complex interactions between genetics and environment in mediating CAD risk [95, 96], existing linear risk prediction models including genetic risk often do not capture genegene or gene-environmental interactions in risk assessment [97,98,99,100]

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