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Overall, it is also crucial to consider the risk of enteric infection when prescribing PPIs

The portal vein which carries blood from the intestinal tract to the liver is the most important route for gut microbiota to communicate with the liver

This response is dynamic and depends on the exposure of the organism to exogenous substances, as well as the microbial components, metabolites, and local microenvironment

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Such compounds are able to inhibit SystemX c , thus leading to exhaustion of cysteine in cells, GPX4 inactivation, accumulated lipid peroxides, and eventually ferroptotic cell death