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The condition is called blackwater fever. The red blood cells burst open and release their hemoglobin, and these get into the urine

However, it is not known whether vitamin B 12 supplementation, in addition to folic acid supplementation, may be beneficial in the prevention of NTD (62) randomized controlled trials are needed to address this question

You really don't want to be taking that one

Patients with pernicious anemia or others who cannot absorb B from food typically need lifelong B therapy, often on a monthly injection schedule

Always consult your prescribing clinician before combining supplements with your medication, and monitor energy and gastrointestinal tolerability over the first 2 to 3 weeks