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Genetic damage in Parkin, PTEN Induced Kinase 1 (PINK1) genes and in the DJ-1 protein (which acts as a neuroprotective redox sensor) result in decreased activity of mitochondrial complex I enzyme and decreased adenosine triphosphate (ATP) production (Greco et al., 2023

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Curcumin may upregulate glutathione synthesis enzymes through activation of the Nrf2 antioxidant response element pathway (Balogun et al., 2003)

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