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Common side effects of the nasal spray may include headaches, weakness, inflamed tongue, tingling sensations in arms/legs, nausea, or a stuffy nose

Importantly, methylated esters of TCA intermediates, such as DMF, are cell permeable and can modify the activity of this pathway by increasing the level of metabolic intermediates' proximate to fumarate

When bound to copper, it becomes biologically active and supports a range of healing and regenerative processes

Additionally, PKC can lead to insulin resistance and exacerbate insulin dysfunction (80)

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