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Patients with vitamin B12 deficiency and concurrent renal or hepatic disease may require increased doses or more frequent administration of cyanocobalamin

18,19 While PDE-5 inhibitors have revolutionized the management of ED, the remainder of this review will focus on alternative treatment options and potential treatment strategies in the setting of failed PDE-5 inhibitor therapy or contraindications
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*** Use of sustained-release glucocorticoid formulations may result in detectable glucocorticoid levels past the washout period due to prolonged systemic absorption
