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Description
Inthavong, K., Tian, Z.F., Tu, J.Y., Yang, W
L., Garcia-Reyero N
This is why conservative starting doses of 0.5 to 2 mg are recommended, compared to the relatively higher starting point of 2.5 mg for tirzepatide

Inhibitors of the MDM2/p53 interaction, such as UBX0101 and RG7112 (RO5045337), and inhibition of the de-ubiquitinating ubiquitin-specific peptidase 7 (USP7) increase and stabilize p53 levels and have been investigated for their senolytic effects
J Am Soc Nephrol 32:3197