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The biggest one is stacked GI side effects - nausea, vomiting, diarrhea, and constipation - because both compounds slow digestion

Neuropharmacology 36 : 111

Some are barely noticeable, others form deeper, clearly visible indents in the body

Molecular changes in the GSH antioxidant system and disturbances in GSH homeostasis have been implicated in tumor initiation, progression, and treatment response

Risks Because the duodenum is bypassed, limited absorption of iron and calcium can result in iron deficiency anemia, bone calcium loss and metabolic bone disease in some patients