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Consequently, left ventricular end-diastolic pressure rises precipitously, causing a dramatic fall in forward stroke volume that manifests as profound hypotension, weak pulses, pallor, and reflex tachycardia

fed wild-type mice, Nrf2 knockout mice, and Keap1 knockout mice with DDC to induce cholangitis

All the mice were weighed and gavaged orally at 200 mg/kg body weight with freshly prepared 2

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(60 g ) with the off-brake setting for 1 min at room temperature