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However, attempts were also made to stabilise the GLP-1 molecule against DPP-4 and also to prevent its high renal clearance rate, which in itself would result in an IV half-life of 30 min

Pathological Mechanisms Underlying Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
K.MantriS.et al (2010)

Nevertheless, a prolonged oxidative imbalancecharacterized by ROS production surpassing the capacity of endogenous antioxidantsleads to molecular alterations, such as protein oxidation and lipid peroxidation

doi: 10.3389/fonc.2022.961970
