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The pathophysiology of ROP evolves in critical hyperoxic and hypoxic phases with key enzymatic pathways such as VEGF, erythropoietin (EPO) and IGF-1 among others to play important roles in each phase (225227)
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Incorporating pain management strategies, such as analgesic use or nerve block therapies, along with advanced wound care, can optimize physical and psychological comfort and outcomes

Similarly, Ru atoms in Ru-oxide maintain a positive valence state as well

Horm Res (2003) 59(4):16179