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As the expression levels of OCTN2 and ATB 0,+ are higher in colon cancer cells than in normal colon cells, LC-PLGA NPs can be used to deliver chemotherapeutic drugs selectively to cancer cells for colon cancer therapy

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(2) L.M.Fitzgerald, J.L.Fryer, T.Dwyer, and S.M.Humphrey (2006) Effect of MELANOTAN, [Nle(4), D-Phe(7)]-alpha-MSH, on melanin synthesis in humans with MC1R variant alleles Peptides, Volume 27, Issue 2, February 2006, Pages 388-394