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Phase 2 dose-finding trial (Lancet 2021) showed clear dose-response from 0.3 mg up to 4.5 mg/week, but 2.4 mg is the dose Novo Nordisk advanced into Phase 3 and is the most commonly self-reported community ceiling

These higher dosages are typically for treating deficiencies rather than for ongoing maintenance

However, fatigue can have many causes, so evaluation from a healthcare provider is recommended

B12 injections bypass the gut, making them especially useful in these cases

Changes in other aspects of cellular integrity can increase or decrease both the sensitivity and selectivity of screening methods used for cytotoxicity studies
