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Mutaciones en el gen de supresin tumoral p53 estn presentes en el 40-50% de todos los cnceres de la piel, esta mutacin permite que clulas daadas proliferen y puedan progresar a cncer (51)

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found that DIV-1 (regulatory subunit) is indispensable for GLP-1/Notch-mediated germ cell proliferation during early larval development, whereas POLA-1 (catalytic subunit) and two primase subunits, PRI-1 and PRI-2, play a crucial role in GLP-1/Notch-mediated maintenance of proliferative cell fate during adulthood [17]