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At therapeutic APAP doses or when liver GSH levels are high, NAPQI is rapidly conjugated with GSH resulting in non-toxic mercapturic acid and cysteine conjugates, which are secreted in the urine

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Among the treatment options, dietary interventions, probiotics, and faecal microbiota transplantation are some noteworthy approaches [11,79]

Though not a direct transcriptional target, c-Myc expression in tumors and TAMs has been shown to drive MMP-9 secretion

10.1016/S0378-5173(98)00212-9 242 PerkinsG