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These cumulative pathological changes contribute to the principal clinical manifestations of PD: (1) the classic motor symptoms (resting tremor, bradykinesia, rigidity, and postural instability) are primarily associated with dopaminergic circuit degeneration [6, 18]

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In addition, a MAGPIX Multiplex Reader was used to measure 25 inflammatory mediators simultaneously in plasma from female [Young ( n = 8), Old Con ( n = 15), and Old mAb ( n = 16)] and male mice [Young ( n = 8), Old Con ( n = 14), and Old mAb ( n = 16)], including: G-CSF, GM-CSF, IFN-, IL-1, IL-1, IL-2, IL-4, IL-5, IL-6, IL-7, IL-9, IL-10, IL-12 (p40), IL-12 (p70), IL-13, IL-15, IL-17, CXCL-10, CXCL-1, MCP-1, MIP-1, MIP-1, MIP-2, RANTES, and TNF- (MCYTOMAG-70K-PMX

doi: 10.3389/fimmu.2017.01239 38 GriffithOWMeisterA

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