how does b12 injections work Best Vitamin Injection Site: Administering B12 Shots Sublingual B12 vs. B12 Injections:
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I am now 115 pounds, my usual weight

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For most patients with vitamin B12 deficiency, high-dose oral supplements are as effective as intramuscular injections at raising serum B12 levels and resolving symptoms

E., Turnbaugh, P

Preferred for patients with MTHFR mutations (which are common in the general population) and for patients who want the most directly usable form