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The company has committed $20 million to continue research on the supplement over the next three years, including through partnerships with leading universities for discovery research on advancing nutrition science

doi: 10.1142/S0192415X02000235

[DOI] [PMC free article] [PubMed] [Google Scholar] 21.Lim S., Shin J., Cho Y., Kim K.P

Effect of Lacticaseibacillus paracasei strain Shirota supplementation on clinical responses and gut microbiome in Parkinsons disease

Studies have shown that A1AR activation upregulates the protective factor IL-11 through activation of ERK and hypoxia-inducible factor 1-, as well as induces cytoprotective heat shock protein 27 (HSP27) synthesis through p38 MAPK activation phosphorylation, thereby reducing renal tubular apoptosis and inflammation [51]