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65 When considering the evidence that the gut microbiota produces TMA, 6 which is then converted into TMAO, and the observed links between increased plasma TMAO levels and adverse cardiovascular events, 10-18 the conclusion that the microbiota plays a mediating role in linking diet and CVD is strengthened

YangSLiXYangFZhaoRPanXLiangJet alGut microbiota-dependent marker TMAO in promoting cardiovascular disease: inflammation mechanism, clinical prognostic, and potential as a therapeutic target

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In addition, probiotics lower inflammation by triggering anti-inflammatory cytokines and reducing pro-inflammatory cytokines that regulate the NF-B pathway [147], which is linked to MAPK, pathogen recognition, and inflammatory signaling pathways [148]

Effect of acetyl-L-carnitine treatment on some behavioural, histochemical and histological parameters of methylazoxymethanol microencephalic rats