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This subpopulation of LARS B cells shows a preference for Leu metabolism, which can be induced by a Leu diet to promote mitochondrial NAD + production and oxidative metabolism and recruit NAD + -dependent protein deacetylase SIRTUIN-1 (SIRT1) to participate in the regulation of LARS B cells

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NAD+, A Non-Peptide Coenzyme Nicotinamide adenine dinucleotide (NAD) is not a peptide since the connection between adenine and nicotinamide is not a peptide bond but instead what is known as a glycosidic bond