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Mechanistically, exercise-induced microbial metabolic reprogramming generates cardioprotective molecules: 3-hydroxypyridinecarboxylic acid (3-HPA) and 4-hydroxybenzoic acid (4-HBA) activate the Nrf2-ARE pathway, reducing cardiomyocyte apoptosis by 42% and suppressing TGF-/Smad3-mediated collagen deposition, ultimately limiting infarct size (Zhou et al., 2022)

as well as by Third Term Comprehensive Control Research for Cancer, Health and Labor Sciences Research Grant to T.T

Due of lack of clear evidences on cupping therapy, it is controversial to use in stroke as an alternative therapy

Enhanced blood flow helps deliver vital nutrients and oxygen to the knee joint, supporting faster recovery and reducing discomfort

In this study, Sc GSH1, Sc GSH2, and St GshF were heterologously expressed in Pichia pastoris GS115 to realize the dual-path synthesis of GSH in yeast