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This observation is supported by clinical studies showing that chronic stress and dysregulation of the stress response were found to contribute to the maintenance and propagation of various CSCs in patients suffering from chronic stress, anxiety, depression, and suicidal behaviour [226, 251, 252]

Abraham N, Schroeter KL, Zhu Y, Chan J, Evans N, Kimber MS, Carere J, Zhou T, Seah SYK (2022b) Structure-function characterization of an aldo-keto reductase involved in detoxification of the mycotoxin, deoxynivalenol

Lin A, Turner Z, Doerrer SC, Stanfield A, Kossoff EH

The April 2024 paper and a comprehensive 2023 Pharmaceuticals review (PMC10224484) detail how peripheral BPC-157 administration produces corresponding central nervous system effects through multiple mechanisms

doi: 10.1056/NEJMoa2312323 52
