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2.2 Epigenetic Modifications Regulate Drug Targets and Bypass Signaling Pathways Over the past decade, targeted agents have been steadily introduced into clinical trials for treating recurrent OC, namely, the anti-VEGFR agent bevacizumab, PARP inhibitors (olaparib, niraparib, and rucaparib), the anti-MEK inhibitor trametinib, and anti-HER2 pertuzumab

Duration and Difficulty: This circuit lasts approximately 2 to 3 hours, depending on the visitors pace and the time spent exploring each area

doi: 10.1021/bi011208f

This is a preview of subscription content, access via your institution Access options Access Nature and 54 other Nature Portfolio journals Get Nature+, our best-value online-access subscription 27,99 / 30 days cancel any time Subscribe to this journal Receive 12 digital issues and online access to articles 118,99 per year only 9,92 per issue Rent or buy this article Prices vary by article type from$1.95 to$39.95 Prices may be subject to local taxes which are calculated during checkout References Magistretti, P

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