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30,31 Although occludin is considered an important TJ component, depletion of occludin in epithelial cells resulted in intact barrier, unaltered permeability, and increased localization of other TAMPs to the junctional area

MishraAPrakashSSreenivasVDasTKAhujaVGuptaSDet al

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This, in turn, boosts metabolic rate and activates a gene known as sirtuin-1 (SIRT1), also referred to as the "longevity gene." SIRT1 is involved in reducing the risk of various conditions such as diabetes, obesity, metabolic syndrome, atherosclerosis, cardiovascular disease, kidney disease, liver disease, neurodegeneration, and cancer.
