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The pivotal role of NAC region in driving the aggregation is also supported by the observation that the second identified pathogenic point mutation V70M (Valine to Methionine) causes predisposition to a sporadic Lewy Body Dementia

Results obtained from preclinical models cannot be directly applied to humans

Regulation of carbohydrate-responsive metabolic genes by histone acetylation and the acetylated histone reader BRD4 in the gene body region

The assumption that SelP is secreted into the bloodstream, as well as several SeCys sequences that are found in its structure, indicates that SePs can become a source of Se for peripheral tissues [20, 21]

Kverneland M, Selmer KK, Nakken KO, Iversen PO, Taubll E