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There are currently no restrictions in the US, according to the Drug Safety Communication

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FIGURE 2 3 Common models for research on blue light damage to eye diseases 3.1 Summary of cell modeling conditions The replication of disease models through ex vivo cells has the advantages of short experimental time, convenient operation, easy observation, good controllability, and reduced use of experimental animals

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And because it is derived from a naturally occurring protein, its mechanism of action works with existing biological pathways rather than introducing foreign signaling