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Some patients report fatigue during tirzepatide treatment, particularly during the early treatment phase or with dose escalation, though this is not among the most common adverse events in clinical trials

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the expression of selenoproteins including plasma selenoprotein P is reduced by inflammatory cytokines resulting in a fall in plasma selenium ( Reference Hesse-Bahr, Dreher and Kohrle 85 , Reference Nichol, Herdman and Sattar 86 )

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