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[Abstract]2025 Nov 4;53(1):44

Considering that this compound has been demonstrated to expand the GSH system along with a reduction in oxidative injury by the AKT/Nrf2 signaling pathway in the hearts of rats and H9C2 cells, the abovementioned enhanced TAC may cover GSH and GSH-dependent antioxidant enzymes [150152]

While it exhibited similar safety parameters to crocin (non-AMES toxic, non-carcinogenic, weak hERG inhibition), its overall CYP inhibitory promiscuity was lower, though it showed some inhibitory behavior, which may necessitate further metabolic profiling

These ligaments help maintain the alignment of the wrist bones, preventing unwanted shifts that could lead to pain and instability

Symptoms include joint inflammation, fever, weight loss and a characteristic facial rash