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While the more obvious route would be directly suppressing TNF, that might not be a good idea because of its important roles in fighting infections and other invaders, which is already a concern for current treatments, they say
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[DOI] [PMC free article] [PubMed] [Google Scholar] 124.Estrela JM, Gil F, Vila JM, Vina J
Cellular morphine tolerance produced by betaarrestin-2-dependent impairment of mu-opioid receptor resensitization
