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Furthermore, an anti-inflammatory probiotic Lactobacillus reuteri , administered over 8 weeks reduced CRP and stress-induced heart rate in Veterans with PTSD and mild traumatic brain injury compared to placebo ( 3.4.4.2 Prebiotics In a male rat model of PTSD-like symptoms induced via amygdala hyperactivation (a key pathophysiological mechanism of PTSD)3 weeks of treatment with the prebiotic GOS restored microbial homeostasis by enriching beneficial Bifidobacterium animalis and Limosilactobacillus reuteri , while eliminating harmful Enterococcus casseliflavus (Ruciski et al., 2025)

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COX-2 is highly inducible in response to growth factors, tumor promoters, and inflammatory cytokines, whereas COX-1 is constitutively expressed in most tissues and fulfils a housekeeping role 33

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