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Another Phase I trial (NCT04629404) was conducted on early-stage PD patients to assess pharmacokinetics, pharmacodynamics, and safety of LY03003, demonstrating well tolerability and promising pharmacodynamic effects, suggesting its suitability for continuous dopaminergic stimulation 141

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They created a prodrug, PARx, that combines their targeted imaging probe with a powerful chemotherapy drug and tested it in the mice

Further details and formalism for the validation metrics used in this work (r 2 , RMSEE, MAE) can also be found in Supplementary Methods

In addition to this, there are some medical conditions like pernicious anemia or gastrointestinal disorders, where malabsorption is the main problem