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Some patients also show distal renal tubular acidosis, based on the same loss of function
Thus, regarding degradative capacity, the two types of Drosophila nephrocytes appeared to show a somewhat inverse trend during ageing, with greater PNC activity in younger cells, while GNCs increased their activity in older animals

G1330A : This mutation results in reduced CBS activity, causing an accumulation of homocysteine in the body

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