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Rather than directly supplying NAD+ precursors (like NMN or NR), it works by blocking an enzyme that consumes nicotinamide, theoretically preserving the substrate pool for endogenous NAD+ production

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[DOI] [PMC free article] [PubMed] [Google Scholar] 20.(U.S.) IoLARGuide for the Care and Use of Laboratory Animals

Xiao, H

You can read more about the link between mitochondrial dysfunction and neurodegenerative disease in the BMG LABTECH blog Mitochondrial dysfunction and neurodegenerative disease