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Food Funct 12:35623571 Zhou N, Bao J (2020) FerrDb: a manually curated resource for regulators and markers of ferroptosis and ferroptosis-disease associations
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Ferroptosis, a form of regulated cell death that is characterized by the iron-dependent accumulation of lipid hydroperoxides, is morphologically and mechanistically different than apoptosis 27,28,29,30,31
Mitochondrial reactive oxygen species (ROS) act as a key regulator, promoting RIPK1 autophosphorylation, which in turn enhances necrosome assembly and MLKL pore-forming capacity, ultimately driving necroptosis (32)
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