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Immune cytokine signatures of PASC patients reflect an ongoing chronic inflammation and angiogenesis with elevated plasma levels of IL-17a, stem cell factor, IL-12p70, IL-1, macrophage inflammatory protein-1 (MIP-1), brain-derived neurotrophic factor (BDNF), and VEGF 223 Also, among other immune mediators, reduced levels of cortisol strongly correlate with pulmonary-PASC symptoms 224

Recent studies have established a close relationship between ferroptosis and ECM degradation (Wilkinson et al., 2019)

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Dihydroartemisinin inhibits the development of colorectal cancer by GSK-3/TCF7/MMP9 pathway and synergies with capecitabine