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demonstrated the efficacy of andrographolide, a diterpene lactone, in protecting the blood-brain barrier by inhibiting the CypA-NF-B-MMP-9 pathway, highlighting its dual anti-inflammatory and neuroprotective effects (Zhou X et al., 2024)

Accumulated evidence indicates that the initiation and progression of CIPN are tightly related with the impairment of chemotherapeutic agent-induced intraepidermal nerve fibers (IENF) [1], oxidative stress [2], abnormal spontaneous discharge, ion channel activation [3], the up-regulation of various pro-inflammatory cytokines, and the activation of the neuro-immune system [4, 5] (Fig

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Ceruloplasmin is an endogenous inhibitor of myeloperoxidase

Gross, A., McDonnell, J