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The first reported GHR antagonist was a bovine GH protein that was mutated with three amino acid substitutions located in helix 3, which resulted in a dwarf phenotype in transgenic mice

Il est utilis dans le traitement et la prvention de la carence en vitamine B12 chez les patients prsentant des affections telles que : Anmie addisonienne (prareuse) Malabsorption Gastrite atrophique Traitement prolong avec la metformine La prolifration bactrienne de l'intestin grle (SIBO) gastrectomie totale ou partielle Infection par le parasite poisson Diphyllobothrium latum infection Helicobacter pylori Dysfonction pancratique Cancer du pancras ou des intestins Carence alimentaire (par exemple, mauvaise nutrition ou rgime vgtalien) Dficience en transcobalamine II Il est galement utilis dans le cadre du test d'absorption de la vitamine B12 (test de Schilling)

They reported it to be 43 amino-acids long and to have some molecular similarities to glucagon

Nijhof IS, Casneuf T, van Velzen J, van Kessel B, Axel AE, Syed K, et al