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Therapeutic strategies targeting metabolic reprogramming in HCC Targeting glycolysis: inhibiting the Warburg effect Mode of action: Inhibiting HK2 or PKM2 can reduce lactate secretion, alleviate TME acidification, and reverse the functional inhibition of CD8 + T cells (such as through PD-L1 down-regulation) [155]

2010;16(3):BR8188

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doi: 10.1080/13854040802003299